Introduction: The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. Patients and methods: A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Both groups are objectively assessed, clinically and laboratory during treatment period till full recovery from burns’ injury. Recall assessment of the drug safety after many years is

Background: Taurine-upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA-377 (miRNA-377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR-γ activators stimulate melanogenesis. Interleukin (IL)-17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA-377, PPAR-γ, and IL-17 among vitiligo

Background: Data have been accumulating in the past few years that identify vitiligo as a disorder with systemic implications. Results and methods: In this hospital-based, cross-sectional, case–control study, 50 patients with non-segmental vitiligo and 50 age- and sex-matched controls underwent analysis of serum lipid profile, oxidative stress biomarkers and carotid duplex. Hydrogen peroxide (H2O2) and malondialdehyde (MDA) were significantly higher in patients than controls (p-value <.001, <.001, respectively); on the other hand, total antioxidant capacity (TAC) was significantly lower in

Cellular respiration is an important process performed by mitochondria. Nad complex is the major complex involved in this process and one of the main subunits in this complex is the nad7 (nad dehydrogenase subunit 7). In Hordeum vulgare subsp. spontaneum, four nad7 cDNAs are described at 500 mM salinity, 0 h, or control (GenBank accession no. MW433884), after 2 h (GenBank accession no. MW433885), after 12 h (GenBank accession no. MW433886) and after 24 h (GenBank accession no. MW433887). Twenty six RNA editing sites were revealed in positions: C44, C45, C77, C83, C99, C137, C224, C244, C251

Introduction: Cancer is one of the most difficult challenges faced by humanity due to its many associated issues, such as inability to prevent diseases, treatment safety, and high mortality rate. In cancer, a variety of cellular signaling is activated to ensure malignancy transformation, angiogenesis and metastasis. The most efficient signaling pathway in cancer is mitogen-activated protein kinase (MAPK), which controls malignancy and regulates apoptosis. Methods: Four different flavonoid glycosides have been isolated from Pulicaria jaubertii using the phytochemical characterization of hydro

This paper reports on the variations in the parameters of the single dispersion Cole bio-impedance model of Daucus Carota Sativus (carrots) under heating and freezing conditions. Experiments are conducted on six samples with recorded live bio-impedance spectra versus temperature. The Cole model parameters are extracted from the measured data using the Flower Pollination Algorithm (FPA) optimization technique and their variations are correlated with well-known bio-chemical and bio-mechanical variations. This represents a non-invasive method for characterizing and measuring the degree of change

One of the many pleasures of living in Egypt is having the opportunity to visit places like a village called Tunis in El-Fayoum governorate which is a touristic village and export art and handicraft such as Pottery for 3-4 decades. The clay processing in the traditional pottery industry contains several stages. The process and quality of the pottery have to be improved to reduce pollution and the manufacturing round time which could be done through improving the heating process. Towards this goal, turbulent three-dimensional numerical simulations for the in-use air inlet and a modified design

A sensitive and a precise method was developed for the quantification of different Sudan dyes in some Egyptian food samples. They were analyzed utilizing two-fragment ion transition under multiple reaction monitoring (MRM) mode. Separation was carried out on Kinetex 2.6u C18 100 A (75 mm × 4.6 mm) phenomenex using isocratic elution with 10:90% water and acetonitrile containing 2.0 mmol/L ammonium formate and 0.2% formic acid. The validation parameters were obtained and verified. The linearity was 0.2–10.0 ng/mL with r2 > 0.9975. LOD and LOQ were 0.06 and 0.19 ng/mL, respectively, for Sudan (I

This paper presents a complete analysis of the mathematical model of the gene regulation process. The model describes the induced gene expression under the effect of activators. The model differential equations are solved analytically, and the exact solution of the gene model is introduced. Moreover, a study of the model dynamics, including the fixed points and stability conditions are presented. The parameters effects on the phase plane portraits and the transient responses of the mRNA as well as the protein concentrations are intensively detailed. This work serves as a brick stone towards a

Soft Robotics is a new approach towards better human-robot interaction and biomimicry in the robotics field. Its integration with biological materials (Biohybrid soft robotics) is one of the topics being focused on in the soft robotics research in the last fifteen years. The motive for this approach is to combine the best of biological and artificial systems. In this article, Biohybrid soft robots and Electronic Skin (E-skin), which is considered one of the advances of soft robotics, are reviewed. Their most significant milestones and the highlights of their most researched applications are